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A causa dell’aumentata esposizione al tadalafil, della limitata esperienza clinica e della mancanza di capacità di influenzare la clearance mediante dialisi, la somministrazione di Cialis una volta al giorno non è raccomandata nei pazienti con grave danno renale.

Nei pazienti che ricevono medicinali antipertensivi concomitanti, il tadalafil può indurre una riduzione della pressione del sangue.

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Cialis è inoltre controindicato nei pazienti che hanno perso la vista da un occhio a causa della neuropatia ottica ischemica anteriore non-arteritica (NAION), indipendentemente dal fatto che questo evento sia o meno correlato al precedente impiego di un inibitore della PDE5.

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